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- Relationship between endogenous intercourse hormone ranges, lipoproteins and coronary atherosclerosis in males undergoing coronary angiography.
- Anabolic androgenic steroid use has increased over the past decade, despite its potential for adverse effects.
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Relationship between endogenous sex hormone levels, lipoproteins and coronary atherosclerosis in men present process coronary angiography. Basaria S, Dobs AS. Risks versus advantages of testosterone therapy in aged men. Scientific and technological services and analysis and design relating thereto; industrial analysis and research services; design and growth of laptop hardware and software program.
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Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood move in men with established coronary artery disease . Therefore, an interplay of endogenous elements of the patient’s risk profile in addition to the testosterone dosing may be issues of whether antagonistic events occur. Erythrocytosis has been reported as a potential effect of testosterone, which can be useful in sufferers with anemia. The best threat of erythrocytosis happens with injectable forms of testosterone in contrast with transdermal preparations, particularly in supraphysiologic doses. An increase of as a lot as 44% of the baseline hematocrit has been reported . Moreover, testosterone has been used within the treatment of lowered muscle mass and bone density in addition to anemia. The position testosterone might play within the development of heart problems has more and more turn out to be the topic of current curiosity .
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We report a case of an acute ST-segment elevation myocardial infarction in a patient with conventional cardiac threat components utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient also had polycythemia, probably secondary to high-dose testosterone. The patient underwent profitable percutaneous intervention of the proper coronary artery. Physicians and patients ought to pay consideration to the scientific penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity. However, testosterone in physiologic doses could even be helpful in patients with angina , have larger ischemic thresholds and improved high quality of life .
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